Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection.

ABSTRACT:

Background

Influenza is a severe respiratory illness that continually threatens global health. It has been widely known that gut microbiota modulates the host response to protect against influenza infection, but mechanistic details remain largely unknown. Here, we took advantage of the phenomenon of lethal dose 50 (LD₅₀) and metagenomic sequencing analysis to identify specific anti-influenza gut microbes and analyze the underlying mechanism.

Results

Transferring fecal microbes from mice that survive virulent influenza H7N9 infection into antibiotic-treated mice confers resistance to infection. Some gut microbes exhibit differential features to lethal influenza infection depending on the infection outcome. Bifidobacterium pseudolongum and Bifidobacterium animalis l

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC7187530 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature