Self-reactive T cells induce and perpetuate chronic relapsing arthritis.

ABSTRACT:

Background

CD4⁺ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the current study was to obtain conclusive evidence that T cells drive chronic relapsing arthritis.

Methods

We used the rat pristane-induced arthritis model, which accurately portrays the chronic relapsing-remitting disease course of RA, to examine the contribution of T cells to chronic arthritis.

Results

Rats subjected to whole-body irradiation and injected with CD4⁺ T cells from lymph nodes of pristane-injected donors developed chronic arthritis that lasted for more than 4 months, whereas T cells from the spleen only induced acute dis

SUBMITTER: Tuncel J 

PROVIDER: S-EPMC7187533 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature