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Emergence of an NDM-5-Producing Hypervirulent Klebsiella pneumoniae Sequence Type 35 Strain with Chromosomal Integration of an Integrative and Conjugative Element, ICEKp1.

ABSTRACT: Here, we report an NDM-5-producing sequence type 35 (ST35) hypervirulent Klebsiella pneumoniae strain, isolated from the blood of a male patient. It showed a remarkable resistance to serum killing and neutrophil phagocytosis and high virulence in a mouse peritonitis infection model. Instead of carrying a pLVPK-like virulence plasmid, chromosomal integration of ICEKp1 (?76?kb) was identified in a specific asparagine-tRNA gene, harboring the iron acquisition system salmochelin genes (iroBCDN), a yersiniabactin gene, and a variant of the rmpA gene.

SUBMITTER: Shen Z 

PROVIDER: S-EPMC7187603 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Emergence of an NDM-5-Producing Hypervirulent Klebsiella pneumoniae Sequence Type 35 Strain with Chromosomal Integration of an Integrative and Conjugative Element, ICE<i>Kp1</i>.

Shen Zhen Z   Gao Qianqian Q   Qin Juanxiu J   Liu Yao Y   Li Min M  

Antimicrobial agents and chemotherapy 20191220 1

Here, we report an NDM-5-producing sequence type 35 (ST35) hypervirulent <i>Klebsiella pneumoniae</i> strain, isolated from the blood of a male patient. It showed a remarkable resistance to serum killing and neutrophil phagocytosis and high virulence in a mouse peritonitis infection model. Instead of carrying a pLVPK-like virulence plasmid, chromosomal integration of ICE<i>Kp1</i> (∼76 kb) was identified in a specific asparagine-tRNA gene, harboring the iron acquisition system salmochelin genes  ...[more]

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