Crotamine in Crotalus durissus: distribution according to subspecies and geographic origin, in captivity or nature.

ABSTRACT:

Background

Crotalus durissus is considered one of the most important species of venomous snakes in Brazil, due to the high mortality of its snakebites. The venom of Crotalus durissus contains four main toxins: crotoxin, convulxin, gyroxin and crotamine. Venoms can vary in their crotamine content, being crotamine-negative or -positive. This heterogeneity is of great importance for producing antivenom, due to their different mechanisms of action. The possibility that antivenom produced by Butantan Institute might have a different immunorecognition capacity between crotamine-negative and crotamine-positive C. durissus venoms instigated us to investigate the differences between these two venom groups.

Methods

The presence of crotamine was analyzed by SDS-PAG

SUBMITTER: Tasima LJ 

PROVIDER: S-EPMC7187639 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature