Enhanced Synthetic Access to Tris-CF₃-Substituted Corroles.

ABSTRACT: Separate focus on the oligomerization and oxidative cyclization steps required for the synthesis of 5,10,15-tris(trifluoromethyl)corrole revealed [bis(trifluoroacetoxy)iodo]benzene (PIFA) as a superior alternative oxidant. Under optimized conditions, the pure free-base corrole was obtained with a 6-fold increase in chemical yield and an 11-fold rise in isolated material per synthesis. The corresponding gallium(III) and manganese(III) complexes were isolated by adding the appropriate metal salt prior to corrole purification.

SUBMITTER: Yadav P 

PROVIDER: S-EPMC7187640 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature