Cardiac arrhythmias in Dravet syndrome: an observational multicenter study.

ABSTRACT:

Objectives

We ascertained the prevalence of ictal arrhythmias to explain the high rate of sudden unexpected death in epilepsy (SUDEP) in Dravet syndrome (DS).

Methods

We selected cases with clinical DS, ≥6 years, SCN1A mutation, and ≥1 seizure/week. Home-based ECG recordings were performed for 20 days continuously. Cases were matched for age and sex to two epilepsy controls with no DS and ≥1 major motor seizure during video-EEG. We determined the prevalence of peri-ictal asystole, bradycardia, QTc changes, and effects of convulsive seizures (CS) on heart rate, heart rate variability (HRV), and PR/QRS. Generalized estimating equations were used to account for multiple seizures within subjects, seizure type, and sleep/wakefulness.

Results

We included 59 cases. Ictal rec

SUBMITTER: Shmuely S 

PROVIDER: S-EPMC7187713 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature