Gut microbiome variation is associated to Multiple Sclerosis phenotypic subtypes.

ABSTRACT:

Objective

Multiple sclerosis (MS) is a heterogenous, inflammatory disease of the central nervous system. Microbiota alterations in MS versus healthy controls (HC) are observed, but results are inconsistent. We studied diversity, enterotypes, and specific gut microbial taxa variation between MS and HC, and between MS subgroups.

Methods

Amplicon sequencing of the 16S ribosomal RNA V4 region (Illumina MiSeq) was used to evaluate alpha and beta diversity, enterotypes, and relative taxa abundances on stool samples. MS subgroups were based on phenotype, disease course modifiers, and treatment status. Results were controlled for recently identified confounders of microbiota composition.

Results

Ninety-eight MS patients and 120 HC were included. Microbial richness was lower i

SUBMITTER: Reynders T 

PROVIDER: S-EPMC7187717 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature