Gray matter network reorganization in multiple sclerosis from 7-Tesla and 3-Tesla MRI data.

ABSTRACT:

Objective

The objective of this study was to determine the ability of 7T-MRI for characterizing brain tissue integrity in early relapsing-remitting MS patients compared to conventional 3T-MRI and to investigate whether 7T-MRI improves the performance for detecting cortical gray matter neurodegeneration and its associated network reorganization dynamics.

Methods

Seven early relapsing-remitting MS patients and seven healthy individuals received MRI at 7T and 3T, whereas 30 and 40 healthy controls underwent separate 3T- and 7T-MRI sessions, respectively. Surface-based cortical thickness (CT) and gray-to-white contrast (GWc) measures were used to model morphometric networks, analyzed with graph theory by means of modularity, clustering coefficient, path length, and small-worldne

SUBMITTER: Gonzalez-Escamilla G 

PROVIDER: S-EPMC7187719 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature