Synaptic transmission may provide an evolutionary benefit to HIV through modulation of latency.

ABSTRACT: Transmission of HIV is known to occur by two mechanisms in vivo: the free virus pathway, where viral particles bud off an infected cell before attaching to an uninfected cell, and the cell-cell pathway, where infected cells form virological synapses through close contact with an uninfected cell. It has also been shown that HIV replication includes a positive feedback loop controlled by the viral protein Tat, which may act as a stochastic switch in determining whether an infected cell enters latency. In this paper, we introduce a simple mathematical model of HIV replication containing both the free virus and cell-cell pathways. Using this model, we demonstrate that the high multiplicity of infection in cell-cell transmission results in a suppression of latent infection, and that this modula

SUBMITTER: Vargas-Garcia C 

PROVIDER: S-EPMC7187919 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature