Longitudinal assessment of interstitial lung disease in single lung transplant recipients with scleroderma.

ABSTRACT: OBJECTIVE:To investigate the natural history of fibrotic lung disease in recipients of a single lung transplant for scleroderma-associated interstitial lung disease (ILD). METHODS:Global ILD (including ground glass, nodular opacities and fibrosis) was categorized into severity quintiles on first and last post-transplant CT scans, and percent fibrosis by manual contouring was also determined, in nine single lung transplant recipients. Quantitative mean lung densities and volumes for the native and allograft lungs were also acquired. RESULTS:In the native lung, global ILD severity quintile worsened in two cases and percent fibrosis worsened in four cases (range 5-28%). In the lung allograft, one case each developed mild, moderate and severe ILD; of these, new fibrotic ILD (involving <10% of

SUBMITTER: Hinze AM 

PROVIDER: S-EPMC7188227 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature