Lurasidone Improves Psychopathology and Cognition in Treatment-Resistant Schizophrenia.

ABSTRACT:

Purpose/background

In addition to clozapine, other atypical antipsychotic drugs pharmacologically similar to clozapine, for example, olanzapine, risperidone, and melperone, are also effective in a similar proportion of treatment-resistant schizophrenia (TRS) patients, ~40%. The major goal of this study was to compare 2 doses of lurasidone, another atypical antipsychotic drug, and time to improvement in psychopathology and cognition during a 6-month trial in TRS patients.

Methods/procedures

The diagnosis of TRS was based on clinical history and lack of improvement in psychopathology during a 6-week open trial of lurasidone 80 mg/d (phase 1). This was followed by a randomized, double-blind, 24-week trial of lurasidone, comparing 80- and 240-mg/d doses (phase 2).

Findings/re

SUBMITTER: Meltzer HY 

PROVIDER: S-EPMC7188269 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature