Differential DNA methylation following chemotherapy for breast cancer is associated with lack of memory improvement at one year.

ABSTRACT: The biological basis underlying cognitive dysfunction in women with early-stage breast cancer (BC) remains unclear, but could reflect gene expression changes that arise from the acquisition and long-term retention of soma-wide alterations in DNA methylation in response to chemotherapy. In this longitudinal study, we identified differences in peripheral methylation patterns present in women prior to treatment (T1) and 1 year after receiving chemotherapy (T4) and evaluated relationships among the differential methylation (DM) ratios with changes in cognitive function. A total of 58 paired (T1 and T4) blood specimens were evaluated. Methylation values were determined for DNA isolated from whole blood using a genome-wide array . Cognitive function was measured using the validated, computerized

SUBMITTER: Yang GS 

PROVIDER: S-EPMC7188391 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature