The Efficacy, Safety, and Optimal Regimen of Corticosteroids in Sepsis: A Bayesian Network Meta-Analysis.

ABSTRACT: Conventional systematic reviews have indicated that corticosteroids might result in a slight reduction in mortality in sepsis. However, the efficacy, safety, and optimal regimen of different corticosteroids partly remain unknown. In this study, we conducted a Bayesian network meta-analysis for a head-to-head comparison of the therapeutic efficacy and safety of currently used corticosteroids in sepsis.

Design

A Bayesian network meta-analysis for a head-to-head comparison of the therapeutic efficacy and safety of currently used corticosteroids in sepsis.

Setting

A total of 35 eligible randomized controlled trials of corticosteroid use in sepsis.

Patients

The present Bayesian network meta-analysis included 8,859 patients with sepsis.

Interventions

Randomized contro

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7188436 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature