Overexpression of CD36 in mammary fibroblasts suppresses colony growth in breast cancer cell lines.

ABSTRACT: Human breast tumors are not fully autonomous. They are dependent on nutrients and growth-promoting signals provided by the supporting stromal cells. Within the tumor microenvironment, one of the secreted macromolecules by tumor cells is activin A, where we show to downregulate CD36 in fibroblasts. Downregulation of CD36 in fibroblasts also increases the secretion of activin A by fibroblasts. We hypothesize that overexpression of CD36 in fibroblasts inhibits the formation of solid tumors in subtypes of breast cancer models. For the first time, we show that co-culturing organoid models of breast cancer cell lines of MDA-MB-231 (e.g., a triple-negative line) or MCF7 (e.g., a luminal-A line) with CD36⁺ fibroblasts inhibit the growth and normalizes basal and lateral polarities, respe

SUBMITTER: Cheng Q 

PROVIDER: S-EPMC7188558 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature