The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder.

ABSTRACT: Bipolar Disorder is costly and debilitating, and many treatments have side effects. Transcranial Direct Current Stimulation (tDCS) is a well-tolerated neuromodulation technique that may be a useful treatment for Bipolar Disorder if targeted to neural regions implicated in the disorder. One potential region is the left ventrolateral prefrontal cortex (vlPFC), which shows abnormally elevated activity during reward expectancy in individuals with Bipolar Disorder. We used a counterbalanced repeated measures design to assess the impact of cathodal (inhibitory) tDCS over the left vlPFC on reward circuitry activity, functional connectivity, and affect in adults with Bipolar Disorder, as a step toward developing novel interventions for individuals with the disorder. -1mA cathodal tDCS was administ

SUBMITTER: Bertocci MA 

PROVIDER: S-EPMC7188575 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature