MiR-27a is a master regulator of metabolic reprogramming and chemoresistance in colorectal cancer.

ABSTRACT:

Background

Metabolic reprogramming towards aerobic glycolysis in cancer supports unrestricted cell proliferation, survival and chemoresistance. The molecular bases of these processes are still undefined. Recent reports suggest crucial roles for microRNAs. Here, we provide new evidence of the implication of miR-27a in modulating colorectal cancer (CRC) metabolism and chemoresistance.

Methods

A survey of miR-27a expression profile in TCGA-COAD dataset revealed that miR-27a-overexpressing CRCs are enriched in gene signatures of mitochondrial dysfunction, deregulated oxidative phosphorylation, mTOR activation and reduced chemosensitivity. The same pathways were analysed in cell lines in which we modified miR-27a levels. The response to chemotherapy was investigated in an indepen

SUBMITTER: Barisciano G 

PROVIDER: S-EPMC7188668 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature