Effects of β₂-receptor stimulation by indacaterol in chronic heart failure treated with selective or non-selective β-blockers: a randomized trial.

ABSTRACT: Alveolar β₂-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β₂-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in HF patients treated with a selective (bisoprolol) or a non-selective (carvedilol) β-blocker. Study procedures were performed before and after indacaterol and placebo treatments according to a cross-over, randomized, double-blind protocol in forty-four patients (27 on bisoprolol and 17 on carvedilol). No differences between indacaterol and placebo were observed in the whole population except for a significantly higher VE/VCO₂ slope and lower max

SUBMITTER: Contini M 

PROVIDER: S-EPMC7188807 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature