Ly6c^Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

ABSTRACT: Perinatal hepatic inflammation can have devastating consequences. Monocytes play an important role in the initiation and resolution of inflammation, and their diverse functions can be attributed to specific cellular subsets: pro-inflammatory or classical monocytes (Ly6c^Hi) and pro-reparative or non-classical monocytes (Ly6c^Lo). We hypothesized that inherent differences in Ly6c^Hi classical monocytes and Ly6c^Lo non-classical monocytes determine susceptibility to perinatal hepatic inflammation in late gestation fetuses and neonates. We found an anti-inflammatory transcriptional profile expressed by Ly6c^Lo non-classical monocytes, and a physiologic abundance of these cells in the late gestation fetal liver. Unlike neonatal pups, late gesta

SUBMITTER: Alkhani A 

PROVIDER: S-EPMC7188847 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature