Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular ¹⁸F-FDG Uptake in Atherosclerotic Mice.

ABSTRACT: This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of ¹⁸F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

SUBMITTER: Stahle M 

PROVIDER: S-EPMC7188869 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature