Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration.

ABSTRACT: Adult skeletal muscle has a remarkable ability to regenerate. Regeneration of mature muscle fibers is dependent on muscle stem cells called satellite cells. Although they are normally in a quiescent state, satellite cells are rapidly activated after injury, and subsequently proliferate and differentiate to make new muscle fibers. Myogenesis is a highly orchestrated biological process and has been extensively studied, and therefore many parameters that can precisely evaluate regenerating events have been established. However, in some cases, it is necessary to evaluate the completion of regeneration rather than ongoing regeneration. In this study, we establish methods for assessing the myofiber maturation during muscle regeneration. By carefully comparing expression patterns of several muscl

SUBMITTER: Yoshimoto Y 

PROVIDER: S-EPMC7188918 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature