Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses.

ABSTRACT: Candida auris has emerged globally as a multidrug-resistant yeast that can spread via nosocomial transmission. An initial phylogenetic study of isolates from Japan, India, Pakistan, South Africa, and Venezuela revealed four populations (clades I, II, III, and IV) corresponding to these geographic regions. Since this description, C. auris has been reported in more than 30 additional countries. To trace this global emergence, we compared the genomes of 304 C. auris isolates from 19 countries on six continents. We found that four predominant clades persist across wide geographic locations. We observed phylogeographic mixing in most clades; clade IV, with isolates mainly from South America, demonstrated the strongest phylogeographic substructure. C. auris isolates f

SUBMITTER: Chow NA 

PROVIDER: S-EPMC7188998 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature