A Novel, Integrative Approach for Evaluating Progression in Multiple Sclerosis: Development of a Scoring Algorithm.

ABSTRACT: BACKGROUND:There is an unmet need for a tool that helps to evaluate patients who are at risk of progressing from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS). A new tool supporting the evaluation of early signs suggestive of progression in multiple sclerosis (MS) has been developed. In the initial stage, concepts relevant to progression were identified using a mixed method approach involving regression on data from a real-world observational study and qualitative research with patients and physicians. The tool was drafted in a questionnaire format to assess these variables. OBJECTIVE:This study aimed to develop the scoring algorithm for the tool, using both quantitative and qualitative research methods. METHODS:The draft scoring algorithm was de

SUBMITTER: Tolley C 

PROVIDER: S-EPMC7189255 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature