Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease.

ABSTRACT:

Background

Growth differentiation factor-15 (GDF-15) is involved in multiple processes that are associated with coronary artery disease (CAD). However, little is known about the association between GDF-15 and the future ischemic events in patients with intermediate CAD. This study was conducted to investigate whether plasma GDF-15 constituted risk biomarkers for future cardiovascular events in patients with intermediate CAD.

Methods

A prospective study was performed based on 541 patients with intermediate CAD (20%-70%). GDF-15 of each patient was determined in a blinded manner. The primary endpoint was major adverse cardiac event (MACE), which was defined as a composite of all-cause death, nonfatal myocardial infarction, revascularization and readmission due to angina pector

SUBMITTER: Wang W 

PROVIDER: S-EPMC7189259 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature