α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells.

ABSTRACT: Hepatocellular carcinoma (HCC) is the most common liver cancer and a major cause of adult death. The current treatments for HCC suffer from drug resistance and poor prognosis; therefore, novel therapeutic agents are urgently needed. Phytochemicals have been proposed to treat a range of cancers. Among them, α-lipoic acid (α-LA), a naturally synthesized antioxidant found in various dietary animal and plant sources, prevents oxidant-mediated cell death in normal cells while inducing apoptosis in several cancer cell lines. Previously, we demonstrated that the treatment of hepatoma cells with α-LA induced apoptosis, which was preceded by the generation of reactive oxygen species (ROS) and activation of the p53 protein, a known inducer of mitochondria-mediated apoptosis. Several studies have sho

SUBMITTER: Pibiri M 

PROVIDER: S-EPMC7189383 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature