Longitudinal assessment of antibiotic resistance gene profiles in gut microbiomes of infants at risk of eczema.

ABSTRACT: BACKGROUND:While there is increasing knowledge about the gut microbiome, the factors influencing and the significance of the gut resistome are still not well understood. Infant gut commensals risk transferring multidrug-resistant antibiotic resistance genes (ARGs) to pathogenic bacteria. The rapid spread of multidrug-resistant pathogenic bacteria is a worldwide public health concern. Better understanding of the naïve infant gut resistome may build the evidence base for antimicrobial stewardship in both humans and in the food industry. Given the high carriage rate of extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in Asia, we aimed to evaluate community prevalence, dynamics, and longitudinal changes in antibiotic resistance gene (ARG) profiles and prevalence of ESBL-pro

SUBMITTER: Loo EXL 

PROVIDER: S-EPMC7189448 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature