Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study.

ABSTRACT: BACKGROUND:Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. METHODS:For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N = 67) and cognitively impaired group (N = 33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N = 198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Trea

SUBMITTER: van de Kreeke JA 

PROVIDER: S-EPMC7189586 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature