The first study of successful pregnancies in Chinese patients with Phenylketonuria.

ABSTRACT:

Background

Since the inception of newborn screening programs in China in the 1990s, pregnancy among patients with inherited, metabolic disorders has become more common. This study explores the management and outcomes of planned, full-term pregnancies in patients with phenylketonuria (PKU).

Method

Married patients with PKU from 2012 to 2017 were enrolled to receive prenatal counseling and regular health assessments. Study-related assessments included the timing of Phe-restricted diets, maternal weight gain, gestational age, pregnancy complications, and blood Phe concentrations (both pre-conception and during pregnancy), obstetrical data, and offspring outcomes(e.g. anthropomorphic measurements and developmental quotients [DQs]).

Results

A total of six offspring were su

SUBMITTER: Wang L 

PROVIDER: S-EPMC7189601 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature