Origin of the nuclear proteome on the basis of pre-existing nuclear localization signals in prokaryotic proteins.

ABSTRACT: BACKGROUND:The origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one of the most important events in the evolution of eukaryotic cells. How proteins were selected for import into the forming nucleus remains an open question. RESULTS:Here, we demonstrate that functional NLSs may be integrated in the nucleotide-binding domains of both eukaryotic and prokaryotic proteins and may coevolve with these domains. CONCLUSION:The presence of sequences similar to NLSs in the DNA-binding domains of prokaryotic proteins might have created an advantage for nuclear accumulation of these proteins during evolution of the nuclear-cytoplasmic barrier, influenci

SUBMITTER: Lisitsyna OM 

PROVIDER: S-EPMC7189692 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature