Eleven loci with new reproducible genetic associations with allergic disease risk.

ABSTRACT:

Background

A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever, and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities.

Objective

We sought to identify novel risk loci shared between asthma, hay fever, and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,838 subjects.

Methods

We used approximate conditional analysis to adjust the results from the published GWAS for the effects of the top risk variants identified in that study. We then analyzed the adjusted GWAS results with the EUGENE gene-based approach, which combines evidence

SUBMITTER: Ferreira MAR 

PROVIDER: S-EPMC7189804 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature