Prospective registration and reporting of trial number in randomised clinical trials: global cross sectional study of the adoption of ICMJE and Declaration of Helsinki recommendations.

ABSTRACT:

Objectives

To evaluate the compliance with prospective registration and inclusion of the trial registration number (TRN) in published randomised controlled trials (RCTs), and to analyse the rationale behind, and detect selective registration bias in, retrospective trial registration.

Design

Cross sectional analysis.

Data sources

PubMed, the 17 World Health Organization's trial registries, University of Toronto library, International Committee of Medical Journal Editors (ICMJE) list of member journals, and the InCites Journal Citation Reports.

Study selection criteria

RCTs registered in any WHO trial registry and published in any PubMed indexed journal in 2018.

Results

This study included 10 500 manuscripts published in 2105 journals. Overall, 71.2% (7473

SUBMITTER: Al-Durra M 

PROVIDER: S-EPMC7190012 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature