Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study.

ABSTRACT:

Objective

To evaluate the risk of adverse maternal and infant outcomes following in utero exposure to duloxetine.

Design

Cohort study nested in the Medicaid Analytic eXtract for 2004-13.

Setting

Publicly insured pregnancies in the United States.

Participants

Pregnant women 18 to 55 years of age and their liveborn infants.

Interventions

Duloxetine exposure during the etiologically relevant time window, compared with no exposure to duloxetine, exposure to selective serotonin reuptake inhibitors, exposure to venlafaxine, and exposure to duloxetine before but not during pregnancy.

Main outcome measures

Congenital malformations overall, cardiac malformations, preterm birth, small for gestational age infant, pre-eclampsia, and postpartum hemorrhage.

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC7190016 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature