Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study.

ABSTRACT:

Objective

To study the impact of maternal smoking during pregnancy on fractures in offspring during different developmental stages of life.

Design

National register based birth cohort study with a sibling comparison design.

Setting

Sweden.

Participants

1 680 307 people born in Sweden between 1983 and 2000 to women who smoked (n=377 367, 22.5%) and did not smoke (n=1 302 940) in early pregnancy. Follow-up was until 31 December 2014.

Main outcome measure

Fractures by attained age up to 32 years.

Results

During a median follow-up of 21.1 years, 377 970 fractures were observed (the overall incidence rate for fracture standardised by calendar year of birth was 11.8 per 1000 person years). The association between maternal smoking during pregnancy and ri

SUBMITTER: Brand JS 

PROVIDER: S-EPMC7190030 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature