Absolute risk of tuberculosis among untreated populations with a positive tuberculin skin test or interferon-gamma release assay result: systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the annual rate of tuberculosis development after a positive tuberculin skin test (TST) or interferon-gamma release assay result (IGRA), or both, among untreated populations with characteristics believed to increase the risk of tuberculosis (at risk populations).

Design

Systematic review and meta-analysis.

Data sources

Embase, Medline, and Cochrane Controlled Register of Trials from 1 January 1990 to 17 May 2019, for studies in humans published in English or French. Reference lists were reviewed.

Eligibility criteria and data analysis

Retrospective or prospective cohorts and randomised trials that included at least 10 untreated participants who tested positive to tuberculosis antigens (contained in TST or IGRA, or both) followed for at le

SUBMITTER: Campbell JR 

PROVIDER: S-EPMC7190060 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature