Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study.

ABSTRACT:

Objective

To evaluate viral loads at different stages of disease progression in patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first four months of the epidemic in Zhejiang province, China.

Design

Retrospective cohort study.

Setting

A designated hospital for patients with covid-19 in Zhejiang province, China.

Participants

96 consecutively admitted patients with laboratory confirmed SARS-CoV-2 infection: 22 with mild disease and 74 with severe disease. Data were collected from 19 January 2020 to 20 March 2020.

Main outcome measures

Ribonucleic acid (RNA) viral load measured in respiratory, stool, serum, and urine samples. Cycle threshold values, a measure of nucleic acid concentration, were plotted

SUBMITTER: Zheng S 

PROVIDER: S-EPMC7190077 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature