Total daily physical activity, brain pathologies, and parkinsonism in older adults.

ABSTRACT:

Objective

We examined the association of physical activity, postmortem brain pathologies, and parkinsonism proximate to death in older adults.

Methods

We studied the brains of 447 older decedents participating in a clinical-autopsy cohort study. We deployed a wrist worn activity monitor to record total daily physical activity during everyday living in the community-setting. Parkinsonism was assessed with 26 items of a modified motor portion of Unified Parkinson's Disease Rating Scale (UPDRS). We used linear regression models, controlling for age and sex, to examine the association of physical activity with parkinsonism with and without indices of Alzheimer's disease and related disorders (ADRD) pathologies. In separate models, we added interaction terms to examine if physica

SUBMITTER: Oveisgharan S 

PROVIDER: S-EPMC7190120 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature