Evaluation of canonical Hedgehog signaling pathway inhibition in canine osteosarcoma.

ABSTRACT: Canine osteosarcoma (OSA), the most common canine primary bone malignancy, has a highly aggressive biologic behavior. Despite current standard of care therapies, including amputation and adjuvant chemotherapy, most dogs still succumb to metastatic disease. Further investigations into molecular mechanisms and pathways driving OSA are needed to improve therapeutic options. The Hedgehog (HH) cell-signaling pathway has demonstrated involvement in human OSA. Several studies in canine OSA have found changes in expression of some HH pathway genes and demonstrated a role for HH transcription factors. However, the role of this pathway as well as the translational value of its targeting in canine OSA are still undefined. The objectives of this study were to determine the expression of HH components

SUBMITTER: Baldanza VE 

PROVIDER: S-EPMC7190150 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature