Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO₃ nanoformulation triggers ferroptosis in target tumor cells.

ABSTRACT: The rapid development of treatment resistance in tumors poses a technological bottleneck in clinical oncology. Ferroptosis is a form of regulated cell death with clinical translational potential, but the efficacy of ferroptosis-inducing agents is susceptible to many endogenous factors when administered alone, for which some cooperating mechanisms are urgently required. Here, we report an amorphous calcium carbonate (ACC)-based nanoassembly for tumor-targeted ferroptosis therapy, in which the totally degradable ACC substrate could synergize with the therapeutic interaction between doxorubicin (DOX) and Fe²⁺. The nanoplatform was simultaneously modified by dendrimers with metalloproteinase-2 (MMP-2)-sheddable PEG or targeting ligands, which offers the functional balance between ci

SUBMITTER: Xue CC 

PROVIDER: S-EPMC7190311 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature