Lineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells.

ABSTRACT: The cellular basis and extent of neural stem cell (NSC) self-renewal in adult vertebrates, and their heterogeneity, remain controversial. To explore the functional behavior and dynamics of individual NSCs, we combined genetic lineage tracing, quantitative clonal analysis, intravital imaging, and global population assessments in the adult zebrafish telencephalon. Our results are compatible with a model where adult neurogenesis is organized in a hierarchy in which a subpopulation of deeply quiescent reservoir NSCs with long-term self-renewal potential generate, through asymmetric divisions, a pool of operational NSCs activating more frequently and taking stochastic fates biased toward neuronal differentiation. Our data further suggest the existence of an additional, upstream, progenitor popu

SUBMITTER: Than-Trong E 

PROVIDER: S-EPMC7190328 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature