Characterizing heart failure with preserved and reduced ejection fraction: An imaging and plasma biomarker approach.

ABSTRACT:

Introduction

The pathophysiology of heart failure with preserved ejection fraction (HFpEF) remains incompletely defined. We aimed to characterize HFpEF compared to heart failure with reduced ejection fraction (HFrEF) and asymptomatic hypertensive or non-hypertensive controls.

Materials and methods

Prospective, observational study of 234 subjects (HFpEF n = 140; HFrEF n = 46, controls n = 48, age 73±8, males 49%) who underwent echocardiography, cardiovascular magnetic resonance imaging (CMR), plasma biomarker analysis (panel of 22) and 6-minute walk testing (6MWT). The primary end-point was the composite of all-cause mortality and/or HF hospitalization.

Results

Compared to controls both HF groups had lower exercise capacity, lower left ventricular (LV) EF, higher LV fi

SUBMITTER: Kanagala P 

PROVIDER: S-EPMC7190371 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature