Risk Factors for and Trends in Isoniazid Monoresistance at Diagnosis of Tuberculosis-United States, 1993-2016.

ABSTRACT:

Context

Resistance to isoniazid (INH) only (monoresistance), with drug susceptibility to rifampin, pyrazinamide, and ethambutol at diagnosis of tuberculosis (TB) disease, can increase the length of treatment.

Objective

To describe US trends in INH monoresistance and associated patient characteristics.

Design

We performed trend and cross-sectional analyses of US National Tuberculosis Surveillance System surveillance data. We used Joinpoint regression to analyze annual trends in INH monoresistance and logistic regression to identify patient characteristics associated with INH monoresistance.

Participants

Culture-positive cases reported to National Tuberculosis Surveillance System during 1993-2016 with drug susceptibility test results to INH, rifampin, pyrazinamid

SUBMITTER: Iqbal SA 

PROVIDER: S-EPMC7190402 | biostudies-literature | 2021 Jul-Aug 01

REPOSITORIES: biostudies-literature