Survival of Older Adults With Newly Diagnosed Acute Myeloid Leukemia: Effect of Using Multiagent Versus Single-agent Chemotherapy.

ABSTRACT:

Background

Controversy exists regarding the optimal chemotherapy regimen for older adults with acute myeloid leukemia (AML).

Patients and methods

We analyzed data from the US National Cancer Data Base of 25,621 patients aged 60 to 79 years, with a diagnosis of AML from 2004 to 2014, who had received single-agent versus multiagent chemotherapy. A Cox proportional hazard model was used for overall survival (OS) analysis for the entire study cohort and separately for patients who had received single-agent (n = 6743) versus multiagent (n = 6743) chemotherapy, matched for age, Charlson comorbidity index, and AML subtype.

Results

The use of multiagent chemotherapy was high overall (70%) but declined with factors, such as increasing age, Charlson comorbidity index, AML subty

SUBMITTER: Bhatt VR 

PROVIDER: S-EPMC7190423 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature