Standardised comparison of limonene-derived monoterpenes identifies structural determinants of anti-inflammatory activity.

ABSTRACT: Mint species are widely used in traditional and conventional medicine as topical analgesics for osteoarthritic pain and for disorders of the gastrointestinal and respiratory tracts which are all associated with chronic inflammation. To identify the structural determinants of anti-inflammatory activity and potency which are required for chemical optimization towards development of new anti-inflammatory drugs, a selected group of monoterpenes especially abundant in mint species was screened by measuring bacterial lipopolysacharide (LPS)-induced nitric oxide (NO) production in murine macrophages. Nine compounds significantly decreased LPS-induced NO production by more than 30%. IC₅₀ values were calculated showing that the order of potency is: (S)-(+)-carvone > (R)-(-)-carvone > (+)

SUBMITTER: Sousa C 

PROVIDER: S-EPMC7190660 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature