Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice.

ABSTRACT: GPRC6A is a widely expressed G-protein coupled receptor that regulates energy metabolism. Global deletion of Gprc6a in mice is reported to result in a metabolic syndrome-like phenotype and conditional deletion of Gprc6a in pancreatic β-cell and skeletal muscle respectively impair insulin secretion and glucose uptake. In the current study, we explore the hepatic functions of GPRC6A by conditionally deleting Gprc6a in hepatocytes by cross breeding Alb-Cre and Gprc6a^flox/flox mice to obtain Gprc6a^Liver-cko mice. Gprc6a^Liver-cko mice on a normal diet showed excessive hepatic fat accumulation and glycogen depletion. These mice also exhibit impaired glucose and pyruvate tolerance, but normal insulin sensitivity. Decreased circulating FGF-21 levels and FGF-21 mess

SUBMITTER: Pi M 

PROVIDER: S-EPMC7190669 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature