Long-Term Aberrations To Cerebellar Endocannabinoids Induced By Early-Life Stress.

ABSTRACT: Emerging evidence points to the role of the endocannabinoid system in long-term stress-induced neural remodeling with studies on stress-induced endocannabinoid dysregulation focusing on cerebral changes that are temporally proximal to stressors. Little is known about temporally distal and sex-specific effects, especially in cerebellum, which is vulnerable to early developmental stress and is dense with cannabinoid receptors. Following limited bedding at postnatal days 2-9, adult (postnatal day 70) cerebellar and hippocampal endocannabinoids, related lipids, and mRNA were assessed, and behavioral performance evaluated. Regional and sex-specific effects were present at baseline and following early-life stress. Limited bedding impaired peripherally-measured basal corticosterone in adult males

SUBMITTER: Moussa-Tooks AB 

PROVIDER: S-EPMC7190863 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature