Genetic Influence on the Sulcal Pits: On the Origin of the First Cortical Folds.

ABSTRACT: The influence of genes on cortical structures has been assessed through various phenotypes. The sulcal pits, which are the putative first cortical folds, have for long been assumed to be under tight genetic control, but this was never quantified. We estimated the pit depth heritability in various brain regions using the high quality and large sample size of the Human Connectome Project pedigree cohort. Analysis of additive genetic variance indicated that their heritability ranges between 0.2 and 0.5 and displays a regional genetic control with an overall symmetric pattern between hemispheres. However, a noticeable asymmetry of heritability estimates is observed in the superior temporal sulcus and could thus be related to language lateralization. The heritability range estimated in this stu

SUBMITTER: Le Guen Y 

PROVIDER: S-EPMC7190941 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature