Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency.

ABSTRACT:

Objective

Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency in Western countries. Patients can suffer from recurrent infections and autoimmune diseases because of a largely unknown aetiology. To increase insights into the pathophysiology of the disease, we studied memory B and T cells and cytokine concentrations in peripheral blood.

Methods

We analysed 30 sIgAD patients (12 children, 18 adults) through detailed phenotyping of peripheral B-cell, CD8⁺ T-cell and CD4⁺ T-cell subsets, sequence analysis of IGA and IGG transcripts, in vitro B-cell activation and blood cytokine measurements.

Results

All patients had significantly decreased numbers of T-cell-dependent (TD; CD27⁺) and T-cell-indep

SUBMITTER: Grosserichter-Wagener C 

PROVIDER: S-EPMC7190975 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature