Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma.

ABSTRACT: The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including melanoma. Despite its therapeutic relevance, characterization of the melanoma immune microenvironments remains insufficiently explored. To distinguish the immune microenvironment in a cohort of 180 metastatic melanoma clinical specimens, we developed a method using promoter CpG methylation of immune cell type-specific genes extracted from genome-wide methylation arrays. Unsupervised clustering identified three immune methylation clusters with varying levels of immune CpG methylation that are related to patient survival. Matching protein and gene expression data further corroborated the identified epigenetic characterization. Exploration of t

SUBMITTER: Mitra S 

PROVIDER: S-EPMC7191190 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature