White matter basis for the hub-and-spoke semantic representation: evidence from semantic dementia.

ABSTRACT: The hub-and-spoke semantic representation theory posits that semantic knowledge is processed in a neural network, which contains an amodal hub, the sensorimotor modality-specific regions, and the connections between them. The exact neural basis of the hub, regions and connectivity remains unclear. Semantic dementia could be an ideal lesion model to construct the semantic network as this disease presents both amodal and modality-specific semantic processing (e.g. colour) deficits. The goal of the present study was to identify, using an unbiased data-driven approach, the semantic hub and its general and modality-specific semantic white matter connections by investigating the relationship between the lesion degree of the network and the severity of semantic deficits in 33 patients with semant

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7191302 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature