Construction of ceRNA Coexpression Network and Screening of Molecular Targets in Colorectal Cancer.

ABSTRACT:

Objective

To screen some RNAs that correlated with colorectal cancer (CRC).

Methods

Differentially expressed miRNAs, lncRNAs, and mRNAs between cancer tissues and normal tissues in CRC were identified using data from the Gene Expression Omnibus (GEO) database. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and protein-protein interactions (PPIs) were performed to do the functional enrichment analysis. And a lncRNA-miRNA-mRNA network was constructed which correlated with CRC. RNAs in this network were subjected to analyze the relationship with the patient prognosis.

Results

A total of 688, 241, and 103 differentially expressed genes (diff-mRNA), diff-lncRNA, and diff-miRNA were obtained between cancer tissues and normal tissues. A total of 315 edges were ob

SUBMITTER: Hui Z 

PROVIDER: S-EPMC7191371 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature