Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review.

ABSTRACT:

Background

Immune parameters (IP) have been extensively studied to distinguish between latent tuberculosis (LTBI) and active tuberculosis (TB).

Objective

To determine the IP associated with LTBI, compared to active TB and individuals not infected by M. tuberculosis published in literature.

Methods

We conducted a systematic search using Google Scholar and PubMed databases, combining the MeSH terms latent tuberculosis, Mycobacterium tuberculosis, cytokines, and biological markers, with the free terms, biomarkers and cytokines. Spanish, English, and Portuguese articles comparing the concentration of IP associated with LTBI, either in plasma/serum or in vitro, in adults and nonimmunocompromised versus individuals with TB or without M. tuberculosis inf

SUBMITTER: Herrera M 

PROVIDER: S-EPMC7191376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature